Fusidic Acid – Topical Antimicrobial in the Management of Staphylococcus Aureus
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چکیده
Fusidic acid (FA) is derived from the fungus Fusidiumcoccineum which was originally isolated from monkey faeces and available in the market since 1962. FA inhibits bacterial protein synthesis by interference with elongation factor G (EF-G), which promotes translocation on the ribosome after peptide bond formation, preventing further elongation by inhibiting the GTPase function of the EF-G. The steroid like structure of FA confers good skin penetration and does not possess the unwanted side effects of steroids.
منابع مشابه
Fusidic acid resistance in community isolates of methicillin-susceptible Staphylococcus aureus and fusidic acid prescribing.
The level of resistance to fusidic acid among community methicillin-susceptible Staphylococcus aureus (MSSA) isolates in the UK and prescriptions for fusidic acid have both doubled over the past 6 years. It is hypothesized that selective pressure arising from topical use of fusidic acid in the community accounts for this increase. A significant correlation was found between prescribing of fusid...
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تاریخ انتشار 2013